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Publications

A range of documents related to HTS and the work of Akina and Dr. Kinam Park from a range of scientific journals.

International Journal of Pharmaceutics

Comparative studies on the properties of glycyrrhetinic acid-loaded PLGA microparticles prepared by emulsion and template methods

3,793.79 KB PDF
The O/W emulsion method has been widely used for the production of poly (lactide-co-glycolide) (PLGA) microparticles. Recently, a template method has been used to make homogeneous microparticles with predefined size and shape, and shown to be useful in encapsulating different types of active compounds.
International Journal of Pharmaceutics
International Journal of Pharmaceutics

Microparticles produced by the hydrogel template method forsustained drug delivery

2,151.30 KB PDF
tPolymeric microparticles have been used widely for sustained drug delivery. Current methods ofmicroparticle production can be improved by making homogeneous particles in size and shape, increas-ing the drug loading, and controlling the initial burst release. In the current study, the hydrogel templatemethod was used to produce homogeneous poly(lactide-co-glycolide) (PLGA) microparticles and toexamine formulation and process-related parameters.
International Journal of Pharmaceutics
Biotechnology Bioprocess Engineering 2001

Microencapsulation Methods for Delivery of Protein Drugs

1,681.49 KB PDF
Biotechnology Bioprocess Engineering 2001
Journal of Controlled Release

A new process for making reservoir-type microcapsules using inkjet technology and interfacial phase separation

456.33 KB PDF
A new microencapsulation technique that utilizes interfacial mass transfer between two mutually soluble liquids has been developed. The technique is based on formation of a solid polymer film at the interface of a solution of a water-insoluble polymer and an aqueous solution, resulting from the mutual mass transfer of solvents (i.e., solvent exchange).
Journal of Controlled Release
Journal of Controlled Release

Issues in long-term protein delivery using biodegradable microparticles

727.86 KB PDF
The important factors in developing biodegradable microparticles for protein drug delivery are protein release profile (including burst release, duration of release, and extent of release), microparticle size, protein loading, encapsulation efficiency, and bioactivity of the released protein.
Journal of Controlled Release
Journal of Controlled Release

A new microencapsulation method using an ultrasonic atomizer based on interfacial solvent exchange

346.82 KB PDF
Reservoir-type microcapsules were produced in a mild and highly efficient manner using a coaxial ultrasonic atomizer. To understand the microencapsulation mechanism, the atomizer was operated in different modes. The results suggested the reservoir-type microcapsules were formed by midair collision of the microdrops of the two component liquids consisting of a polymer solution and an aqueous solution.
Journal of Controlled Release
Journal of Controlled Release

A study of drug release from homogeneous PLGA microstructures

1,092.05 KB PDF
The hydrogel template method was used to fabricate homogeneous drug–PLGA microparticles. Four drugs (felodipine, risperidone, progesterone, and paclitaxel) were loaded into the PLGA particles with the homogeneous size of 10 μm, 20 μm, and 50 μm. The drug loading into the PLGA microparticles was 50% and higher.
Journal of Controlled Release
Encyclopedia of Pharmaceutical Science and Technology

Microencapsulation: Methods and Pharmaceutical Applications

394.04 KB PDF
Microencapsulated particles have become indispensable in controlled drug release systems. Biocompatible microparticles with modifi ed drug release profi les are particularly useful for the development of parenteral formulations. Examples of useful types of modifi ed release profi les include:
Encyclopedia of Pharmaceutical Science and Technology
Journal of Controlled Release

A study of drug release from homogeneous PLGA microstructures

1,056.84 KB PDF
The hydrogel template method allowed preparation of homogeneous particles with predefined sizes with high drug loading. It allowed study on the effect of size and shape on the drug release kinetics. With the microparticles of homogeneous size and shape, the drug release kinetics can be projected based on the size of microparticles and water-solubility of a drug. The ability of making homogeneous particles is expected to provide better prediction and reproducibility of the drug release property of a given formulation.
Journal of Controlled Release
Pharmaceutical Research, Vol. 25, No. 1

Microenvironment-Controlled Encapsulation (MiCE) Process: Effects of PLGA Concentration, Flow Rate, and Collection Method on Microcapsule Size and Morphology

459.53 KB PDF
The MiCE microencapsulation process allows effective monitoring and control of the instrumental parameters affecting microcapsule production. However, the microcapsule collection method in this process needs to be further optimized to obtain microcapsules with desired morphologies, precise membrane thicknesses, high encapsulation efficiencies, and tight size distributions.
Pharmaceutical Research, Vol. 25, No. 1
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